Vantage has more time in the field with panelized lighting. If your not doing panelized then C4 is the best way to go. C4 lighting helps with your zigbee mesh network, Vantage does absolutly nothing for you're zigbee mesh. Programming is easier with C4 Keeping everything C4 will give you greater flexability. Unless your building a 20,000 sq ft house or larger then I really don't see any benefit to using Vantage. Personally, if I were to choose a lighting system other than C4, I would go with Lutron.