If you had asked a couple months ago, I would've said yes. However, the driver was updated recently to remove linking, so all switch linking needs to be done with HouseLinc and then added to C4. I'm not sure if this makes things harder or easier as I haven't had to add any Insteon loads since my initial install.
The tricky part was getting getting the load and slave switches in sync when controlled via C4. Through Composer they would not be in sync and you'd have to click the On or Off twice to get them to work, but through any other navigator (SR-260, C4 app, EA On-Screen) they work perfectly. I don't know if Houselinc changes this, but we had to add both the load and the slave to each room in the project, and then use the Set button on each switch to identify it to the driver, and then bind the switches together in Composer.