This is possible if you use Smart Bridge PRO to integrate your Serena shades. Smart bridge non-pro will not work. You'll want C4 keypads if you want to integrate multiple shade/light scenes. If you want a bit more cost effective route to control shades only (full open/full close, raise/lower, one favorite position for group or single shade), you can use wall/pedestal mounted pico (PJ2-3BRL-GWH-S01 available in different colors). I think you'll be happy with Serenas. I have them installed throughout the house and it's never skip a beat. Also, the only difference after talking with Lutron support is the QS have more options for fabric and colors and sizing. Serena are just as quiet and reliable as the more expensive lines. Caseta is also limited to 75 devices. Each shade, light switch, pico remote, plug-in module, hub is considered one device.