HeadHammer

.....
I think you're all overthinking this too much.
 
Yes, connect the HDMI to the stupid samsung box, connect the samsung box to the TV. Mount the box to the wall - you have a swing arm mount so should have enough room.
Get the approriate driver installed, connect the IR to the front of the TV (or get it changed to the network if reasonable to do, but that's a side question).
 
Done.
 
As far as C4 is concerned there is no 'box' there - it just sees a TV. That the HDMI and audio board is external vs internal (which is basically all that stupid thing is) the system won't care about.

Samsung Q80 is still a damn nice TV without the the One-Connect, and in the pic it looks like there is a cat5 at location being used for IR, you could convert that to network cable and use network driver for TV

Just to clarify your question:
When you say 'plug in the HDMI cable', you're saying you have a single HDMI cable coming from your rack to the TV's location? Do you also have power and network running to the TV location? Is it possible to pull a cable from the TV location to the rack? (i.e. is there a conduit from the rack to the TV location) Do you have only a single source to plug into the TV?  (is there a receiver in the rack, for example) RyanE

i just went through this.  may not directly answer your questions, but some info below
 
- There are no connections on the back of the tv besides the one connect cable port.  it is proprietary to samsung.
- anything you want to connect to the tv needs to go through the one connect box
- on my tv (slightly different, but likely same setup) the power is also routed through the one connect box
- the one connect cable is not rated for in wall use 
- snapav has just released an in-wall backing box that is large enough to accomodate the one connect box called the versabox XL - this was announced literally days after i installed my box.  the previous versaboxes are not big enough to fit the oneconnect box, so i ended up having to cut a giant hole in the box to push half the one connect device behind the wall, a bit of a nightmare.
 
hope this helps, happy to answer any questions,  don't believe there is any way to get out of this, if i was in your situation, id install the larger versabox, store the one connect box directly behind the tv in the wallbox, and then keep my existing cable setup.